Online Case Studies

A Pragmatic Approach to Formalin Safety in Anatomical Pathology

This is a Continuing Education on-line course that describes formalin safety issues in the anatomical pathology laboratory as well as both institutional and personal achievable measures to prevent formaldehyde overexposure. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Lymphocyte Morphology

Abnormal Peripheral Blood Cells

This is a Continuing Education on-line course that compares and contrast morphologic features associated with basophilic stippling, Howell-Jolly bodies, and Pappenheimer bodies on a Wright-stained peripheral blood smear. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Hemoglobin Defects

This is a Continuing Education on-line course that identifies morphologic abnormalities in erythrocytes associated with certain hemoglobinopathies and thalassemias. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Septicemia & Peripheral Blood Cell

This is a Continuing Education on-line course that distinguishes extracellular and intracellular bacteria from contaminants and other cells. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Waldenstrom's Macroglobulinemia

This is a Continuing Education on-line course that identifies morphologic abnormalities in erythrocytes and leukocytes associated with Waldenström's macroglobulinemia. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Acute Lymphocytic Leukemia

This is a Continuing Education on-line course that describes the morphologic features of normal peripheral blood leukocytes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Hairy Cell Leukemia

This is a Continuing Education on-line course that discusses morphological, cytochemical, and immunohistochemical characteristics of lymphocytes associated with hairy cell leukemia. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Hereditary Elliptocytosis

This is a Continuing Education on-line course that discusses morphologic characteristics of normal peripheral blood leukocytes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Chronic Myelocytic Leukemia

This is a Continuing Education on-line course that describes the morphologic features of normal peripheral blood leukocytes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Laboratory Monitoring of Heparin: Challenges and Opportunities

Macroscopic Mimics of Helminths in Stool Specimen Examination

Molecular Tools for the Detection and Characterization of Bacterial Infections: A Review

Multiparametric Flow Cytometry in the Diagnosis of Myelodysplastic Syndromes and Related Disorders

Placental Examination

Point-of-Care Testing: Twenty Years’ Experience

Preimplantation Genetic Diagnosis: Implementation of Molecular Tests in the Clinical Laboratory

Proficiency Testing: A Guide to Maintaining Successful Performance

Reducing the Risk of Transfusion-Transmitted Bacterial Infections in Platelet Concentrates: Current Status and Developments

Root Cause Analysis of Specimen Misidentification in Surgical Pathology Accession and Grossing

Sickle Cell Anemia

This is a Continuing Education on-line course that discusses the pathophysiology of sickle cell disease . Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

The Advantages of Molecular Diagnostics in the Surveillance of Health Care-Associated Infections

Update on Prostate-Specific Antigen Testing for the Early Detection of Prostate Cancer

Urine Cytology and Commercially Available Urine-Based Markers for Monitoring of Bladder Urothelial Carcinoma Chemistry

Vibrio in the United States: Vibrio cholerae and Other Pathogenic Vibrios

Pelger-Huet Anomaly

This is a Continuing Education on-line course that identifies morphologic features of normal peripheral blood leukocytes and platelets. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Sideroblastic Anemia

This is a Continuing Education on-line course that compares and contrasts the morphology of basophilic stippling, Howell Jolly bodies, and Pappenheimer bodies on a Wright’s-stained peripheral blood smear. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Iron Deficiency Anemia

This is a Continuing Education on-line course that identifies morphologic abnormalities in erythrocytes associated with iron deficiency anemia. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Toxic Morphologic Abnormalities in Leukocytes

This is a Continuing Education on-line course that identifies toxic morphologic abnormalities in leukocytes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

May-Hegglin Anomaly

This is a Continuing Education on-line course that identifies morphologic characteristics of mature and immature leukocytes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

A Simple Tool to Educate Laboratory Staff About Anticoagulation

This is a Continuing Education on-line course that lists the different classes of anticoagulants, basic mechanisms of anticoagulation, and the tests used to monitor the different classes of anticoagulants. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Histotechnology: Fixation Exercise 1

This is a Continuing Education on-line course that describes the purspose of fixation. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Fixation Exercise 2

This is a Continuing Education on-line course that identifies the factors that affect the quality of fixation and describes the effect of each factor on tissue (eg, temperature, size of tissue, time of fixation, or osmolality of fixative). Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Fixation Exercise 3

This is a Continuing Education on-line course that identifies the properties, functions, and actions of fixative reagents and solutions. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Fixation Exercise 4

This is a Continuing Education on-line course that describes which fixatives require postfixation washing, the preferred washing agent. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Fixation Exercise 5

This is a Continuing Education on-line course that describes the action of zinc in fixation. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Processing Exercise 1

This is a Continuing Education on-line course that defines dehydration, clearing, infiltration, universal solvent, and miscible. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Processing Exercise 2

This is a Continuing Education on-line course that defines clearing Agents, xylene, toluene, benzene, acetone, chloroform, cedarwood oil, tetrahydrofuran, dioxane, limonene derivatives, and aliphatic hydrocarbons. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Processing Exercise 3

This is a Continuing Education on-line course that describes the possible effects on H&E stains if water is present in the clearing agent on the tissue processor. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Processing Exercise 4

This is a Continuing Education on-line course that defines cross-section, decalcification, ion exchange, and chelating agent. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Processing Exercise 5

This is a Continuing Education on-line course that describes the methods for determining the endpoint of decalcification. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Instrumentation Exercise 1

This is a Continuing Education on-line course that describes the types of microscopy and identify indications for their use. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Instrumentation Exercise 2

This is a Continuing Education on-line course that identifies the different types of microtome blades. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Instrumentation Exercise 3

This is a Continuing Education on-line course that describes the mechanisms of closed tissue-processing systems. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Instrumentation Exercise 4

This is a Continuing Education on-line course that describes the maintenance of laboratory instruments with quality control and/or quality assurance. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Safety Exercise 1

This is a Continuing Education on-line course that lists commonly used toxic chemicals, and their specific hazard(s). Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Safety Exercise 2

This is a Continuing Education on-line course that defines time-weighted average (TWA), permissible exposure limit (PEL), short-term exposure limit (STEL), LD_50, fire triangle, ergonomics, and universal precautions. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Histotechnology: Safety Exercise 3

This is a Continuing Education on-line course that describes the appropriate method of disposal for each of the listed reagents. Read a section from the book Histotechnology: A self-instructional Text and answer an attestation to earn 1 CMLE credit.

Acetaminophen Overdose Testing

This is a Continuing Education on-line course that lists the qualitative urine and quantitative blood tests that laboratories should offer based on the recommendations of the National Academy of Clinical Biochemistry (NACB) guidelines for treatment of the poisoned patient. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

BNP and NT-proBNP

This is a Continuing Education on-line course that discusses factors that affect the interpretation of B-type natriuretic peptide (BNP) and N terminal (NT)-proBNP results. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Arterial Blood Gases

This is a Continuing Education on-line course that lists the tests included in arterial blood gases and discuss their clinical use. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Amphetamines and Related Compounds

This is a Continuing Education on-line course that lists amphetamine-like compounds that may be detected by immunoassay screening tests for amphetamines. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Cardiac Function: Biochemical Markers

This is a Continuing Education on-line course that lists and discusses the recommended biomarkers for diagnosis of myocardial infarction and heart failure. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

C-Peptide and Insulin

This is a Continuing Education on-line course that discusses the use of C-peptide and insulin results to differentiate between Type 1 and Type 2 diabetes mellitus. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

CA 125

This is a Continuing Education on-line course that discusses the use of CA 125 levels in monitoring patients undergoing treatment for ovarian cancer and in the detection of recurrent disease. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

CA 15-3 and CA 27.29

This is a Continuing Education on-line course that discusses the use of CA 15-3 and CA 27.29 levels in monitoring patients undergoing treatment for breast cancer and for the detection of recurrent and metastatic disease. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Cardiac Markers

This is a Continuing Education on-line course that discusses the clinical uses of troponin measurements in addition to diagnosis of a myocardial infarction (MI). Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Thyroid and Parathyroid Testing

This is a Continuing Education on-line course that discusses the symptoms of Hashimoto’s Thyroiditis and Graves Disease. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Urine Drug Testing

This is a Continuing Education on-line course that compares and discusses clinical and workplace drug testing. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Prostate-Specific Antigen (PSA)

This is a Continuing Education on-line course that discusses the use of PSA levels in the diagnosis of prostate cancer. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Method Validation - Calibration and Linearity

This is a Continuing Education on-line course that lists and discusses the CLIA ‘88 standards and interpretive guidelines applying to method and calibration verification of test systems. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Liver Function Enzymes

This is a Continuing Education on-line course that discusses the use of enzyme levels in the diagnosis of liver disease. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Fetal Fibronectin

This is a Continuing Education on-line course that discusses the symptoms and treatment of preterm labor. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Diabetes Testing

This is a Continuing Education on-line course that discusses the criteria for the diagnosis of diabetes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Detecting Premature Rupture of Fetal Membranes (ROM)

This is a Continuing Education on-line course that discusses the problems associated with premature rupture of fetal membranes. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

Contemporary Evaluation of Colorectal Carcinoma in Specimens From Endoscopic Biopsies

This is a Continuing Education on-line course that lists immunostains, histologic features, and mechanisms associated with colorectal carcinoma. Complete a short multiple-choice quiz to earn 1 CMLE credit.

West Nile Virus Update

Allergen-Specific IgE Testing

Rubella Infection: Significance of Testing

HIV/AIDS - Preventing Transmission

Clinical and Laboratory Testing for Allergies

Autoimmune Thyroid Diseases

Testing for Infectious Mononucleosis

Update on Markers for Hepatitis Viruses

This is a Continuing Education on-line course that compares acute and chronic viral hepatitis infections. Complete a short multiple-choice quiz to earn 1 CME/CMLE credit.

High Sensitivity CRP in Cardiovascular Disease

Diagnosing Lyme Disease

Rapid Testing for HIV

Laboratory Testing for Syphilis

Helicobacter Pylori in Ulcer Disease

The Complement System

Use of Rheumatoid Factor in Diagnosis of Rheumatoid Arthritis

Human Immunodeficiency Virus

Red Cell Cytograms Generated by an ADVIA 120 Automated Hematology Analyzer: Characteristic Patterns in Common Hematological Conditions

This is a Continuing Education on-line course that discusses numerical as well as red cell cytogram data generated by the Advia-120 automated hematology analyzer as seen in commonly encountered hematological conditions. Complete a short multiple-choice quiz to earn 1 CMLE credit.

A Rapid and Accurate Method for Stem-Cell-Viability Evaluation: The Case of the Thawed Umbilical Cord Blood

This is a Continuing Education on-line course that describes a rapid method for the cell viability evaluation. This method is as accurate as the trypan blue exclusion test, but one can evaluate simultaneously 96 samples in half an hour. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Clinical Significance of Measuring Prostate Specific Antigen

This is a Continuing Education on-line course that discusses PSA values and assesses the risk of prostate carcinoma using PSA quotient. In addition, errors associated with PSA and PSA quotient measurement are compared and discussed. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Overview of the Flaviviridae With an Emphasis on the Japanese Encephalitis Group Viruses

This is a Continuing Education on-line course that describes Flaviviridae as it pertains to general characteristics and classification with emphasis on the major viral pathogens within the Japanese encephalitis group of the Flavivirus genus. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Reference Range for Umbilical Cord Blood Hematological Values

This is a Continuing Education on-line course that evaluates umbilical cord blood hematological parameters. Some of these parameters are crucial for the further processing and isolation of the hematopoietic progenitor UCB cells, as well as the possibility of increased likelihood of rejection of a sample. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Clinical Laboratory Compliance: Something Old, Something New

This is a Continuing Education on-line course that discusses laboratory billing compliance. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Pancreatic Pathology: A Practical Review

This is a Continuing Education on-line course that discusses ductal adenocarcinoma, in particular histologic features useful in frozen section evaluation and in its distinction from chronic pancreatitis. Complete a short multiple-choice quiz to earn 1 CMLE credit.

HbA_1c Standardization: Background, Progress, and Current Issues

This is a Continuing Education on-line course that discusses and compares various HbA_1c standardization programs and results reporting methods. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Serum Free Light Chain Analysis for Diagnosis, Monitoring, and Prognosis of Monoclonal Gammopathies

This is a Continuing Education on-line course that discusses the utility of serum free light chain analysis and its uses in the diagnosis of monoclonal gammopathy, in monitoring patients with oligosecretory disease, and for prognosis of plasma cell dyscrasia. Complete a short multiple-choice quiz to earn 1 CMLE credit.

A Mystery Diagnosis: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Recessive

This is a Continuing Education on-line course that discusses the cause, symptoms, diagnosis, and treatments of IPEX. Complete a short multiple-choice quiz to earn 1 CMLE credit.

An Overview of Arboviruses and Bunyaviruses

This is a Continuing Education on-line course that discusses arboviruses and their classification, epidemiology, clinical features, diagnosis, treatment, and prevention. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Recent Advances in the Detection of Prostate Cancer Using Epigenetic Markers in Commonly Collected Laboratory Samples

This is a Continuing Education on-line course that discusses epigenetic biomarkers and CpG hypermethylation for the detection of prostate cancer. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Clinical Laboratory Utilization: Which, Why, and What Do The Results Mean?

This is a Continuing Education on-line course that describes the “laboratory testing cycle” and discusses the potential sources of error that can occur in each phase of this cycle. Complete a short multiple-choice quiz to earn 1 CMLE credit.

The Clinical Utility of Tumor Markers

This is a Continuing Education on-line course that describes the expanding range of viable tumor markers, tumor markers that are presently available in the routine clinical laboratory, and clinical applications of markers that are currently in widespread use. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Laboratory Monitoring of Heparin Therapy: PTT or Anti-Xa Assay?

This is a Continuing Education on-line course that describes the physical characteristics and therapeutic uses of heparin. Complete a short multiple-choice quiz to earn 1 CMLE credit.

Von Willebrand Disease: Elucidating the Clinical Picture Through the Use of Molecular Methods

Newborn Screening: What’s New?

Cancer Stem Cells: On the Verge of Clinical Translation

Tissue Localization of Therapy Targets in Cancer: Immunohistochemistry and Beyond

An Update on Immune-Mediated Thrombocytopenia

Autoantibody Biomarkers in Prostate Cancer

Autoimmune Hepatitis: A Brief Review With an Emphasis on Autoimmune Testing

Avian Influenza A (H5N1): Pandemic Potential and the Role of the Clinical Microbiology Laboratory

Bladder Cancer Screening and Future Directions in Urine-Based Markers for Bladder Urothellial Carcinoma

Clinical Significance of Cytogenetics in Myelodysplastic Syndromes

Collection, Processing, and Banking of Umbilical Cord Blood Stem Cells for Clinical Use in Transplantation and Regenerative Medicine

Differential Diagnosis of Weger's Granulomatosis from Other Small Vessel Vasculitides

Electronic Health Records: A Primer

Fasciola hepatica Infection in the United States

Insulin Use in the Hospital: An Evolving Therapeutic Paradigm

Laboratory Assessment of Fetomaternal Hemorrhage is Improved Using Flow Cytometry