Lenacapavir May Inhibit Replication Of HIV-2 Isolates And Drug-Resistant HIV-2 Variants, Study Finds

Infectious Disease Advisor (1/26, Nye) reported, “Lenacapavir may inhibit the replication of HIV-2 isolates and drug-resistant HIV-2 variants, according to results of a study published in The Journal of Infectious Diseases.” In the study, “in an analysis of lenacapavir activity via multicycle 6-day infection assay, the mean IC50 for HIV-2 was 2.4 nM, which was 14-fold higher than that of HIV-1. The mean IC50 for both HIV-1 and HIV-2 isolates significantly differed from that of SIV isolates.”