Shorter Antibiotic Courses May Be Appropriate For Uncomplicated S. Aureus Bacteremia, Study Finds

Infectious Disease Advisor (5/10, Chan) reported, “A shorter course of antibiotics may be appropriate for patients with less severe cases of uncomplicated Staphylococcus aureus bacteremia, according to study results published in Therapeutic Advances in Infectious Disease.” In the study, “in regard to 90-day bacteremia recurrence, data captured from 5 studies (n=864) indicated a reduced risk in patients who received short vs long antibiotic courses (OR, 0.75; 95% CI, 0.31-1.68; P =.45). However, the between-group risk for 90-day bacteremia recurrence was similar in a subanalysis of 3 studies (n=820) in which short and long antibiotic courses were defined as fewer than 14 days vs 14 days and longer, respectively (OR, 1.03; 95% CI, 0.24-4.42; P =.97).”