Study Finds Two Proteins Pair To Allow Toxic Aggregates Of Alpha-Synuclein Into Nerve Cells, Help It Spread Across Brain

Parkinson’s News Today (7/8, Maia) reports, “Two proteins, Aplp1 and Lag3, pair to allow toxic aggregates of alpha-synuclein – a hallmark of Parkinson’s disease – into nerve cells and help it spread across the brain, according to a study in mice.” Researchers “also found that using an antibody against Lag3 blocked the protein’s interaction with Aplp1, keeping alpha-synuclein from being taken into nerve cells and causing neurodegeneration.” The findings were published in Nature Communications.