Self-Reactive Antibodies Against Two Proteins Appear To Be Linked To Higher Risk Of Relapse Among People With ANCA-Associated Vasculitis, Study Finds

ANCA Vasculitis News (11/6, Wexler) reports, “Self-reactive antibodies, or autoantibodies, against two proteins – homeostatic iron regulator, or HFE, and synaptotagmin 5, known as SYT5 – appear to be linked to a higher risk of relapse among people with ANCA-associated vasculitis (AAV), according to a new study.” The “findings suggest that the presence of abnormal antibodies targeting either HFE or SYT5 may be used as potential predictive biomarkers of AAV relapse.” The findings were published in Rheumatology.