Cells Derived From People With SSc Have Widespread DNA Mutations Compared With Healthy Cells, Study Suggests

Scleroderma News Today (11/19, Bryson) reports, “Cells derived from people with systemic sclerosis (SSc) had widespread DNA mutations compared with healthy cells, which may explain the higher risk of cancer in this patient population, according to a study.” Researchers found that “changes included mutational patterns found solely in the genomes of certain cancers, as well as changes in one or two DNA building blocks, insertions and deletions of DNA segments, and alterations in whole chromosomes.” The findings were published in Nature Communications.