Analyses Find Patients With EoE Who Are Responsive To PPIs, Those Who Are Unresponsive Share Similar Esophageal Protein Profiles

GI & Hepatology News (12/18, Crist) reported, “Among patients with eosinophilic esophagitis (EoE), both those who are responsive to proton pump inhibitors (PPIs) and those who are unresponsive to PPI treatment share similar esophageal protein profiles, which are distinct from those without EoE, according to comparative proteomic analyses.” Researchers found that “after PPI therapy, the protein profiles of responsive patients reverted and appeared similar to non-EoE patients, whereas the profiles of nonresponsive patients remained largely unchanged.” The findings were published in Gastroenterology.